Host Defense and Viral Immune Evasion: A Proteomics Perspective
In Plain English:
Human cells and viruses are locked in a protein-based arms race for global domination: Will the cell’s defensive proteins successfully recognize viral DNA and alert the immune system? Or will the virus counter with proteins that stop the defensive proteins in their tracks? The answer is that both of these processes are happening all the time.
Ileana Cristea of Princeton University’s Molecular Biology Department
Harvard Medical School’s Microbiology & Immunobiology department
What it covered:
Full disclosure: I got to the talk about 10 minutes late after being stopped by a security guard (who wasn’t sure how to react to a 22-year-old with a backpack who could speak proteomics-babble but couldn’t produce a student ID). So I missed the first few slides of the talk, but when I arrived, Dr. Cristea was introducing the HMS research crowd to Gamma-Interferon-Inducible Protein 16 (IFI-16) and its role in the innate immune system. Continue reading “Viruses can shut down our anti-viral proteins – Recap of talk by Dr. Ileana Cristea” »
[This post is part of a series called “Brown Bag Lunch Reports” where I recap some of the academic talks given at college campuses in and around the city of Boston. Let me know what you think of the post format and what kinds of talks you think I should recap next!]
The Talk’s Title:
Manipulating natural bioelectric gradients to control growth and form in embryogenesis, regeneration, and cancer
In Plain English:
Changing the ways electric signals flow through living tissues alters the organisms’ growth in profound ways, including (but not limited to) the regeneration of complex organs like eyes and limbs.
Michael Levin, Ph.d. of the Tufts Center for Regenerative Medicine and Developmental Biology
Northeastern University’s Center for Interdisciplinary Research on Complex Systems
What it covered:
Dr. Michael Levin’s lab investigates a little-known (and if half of what he says is true, very underappreciated) topic in biology: the effect of variation in the electric charges of cells on morphological development. If that last sentence sounded like a random string of sciencey-sounding words from different disciplines, there’s a reason for that: Dr. Levin’s work draws heavily from both physics and molecular biology. Continue reading “Bioelectric signals tell organisms when to grow limbs (among other things) – Recap of talk by Dr. Michael Levin” »
What it’s about:
Moises Velasquez-Manoff’s Epidemic of Absence tackles one of the trickiest and trendiest topics in 21st-century biomedical research: the complex relationship between autoimmune disease and the bacteria that live in our guts.
A growing body of evidence suggests that by decimating the number of pathogenic microbes people are exposed to, modern medicine has inadvertently shifted the ecological balance between the human immune system and the human microbiome, leaving millions of people vulnerable to allergies and autoimmune disease.
The basic evolutionary argument is that our immune system evolved to cope with a constant onslaught of opportunistic microbes by developing a complex system of checks-and-balances with our bodies’ microbial populations. With those microbes gone, many of the immune system’s coping strategies are having disastrous side effects. In this book, Velasquez-Manoff implicates the depletion of bacterial biodiversity as a driving agent in the pretty much every non-infectious disease you can think of (cancer, depression, Crohn’s, Celiac’s, allergies, and autism are all covered in this book).
It’s a rare snapshot of a scientific revolution in progress. And it’s easily the most thought-provoking book I’ve read all year. Continue reading “Epidemic of Absence: A book that made me think too much” »
“Scientists, they’re isolated. They’re out of touch with real world concerns, and that’s why they can’t get funding. What can we do get them interested in relevant projects so that they can get their funding?”
This was an audience question at a Nova-sponsored Science Cafe in Cambridge, MA. The speaker was Ari Daniel, an oceanographer-turned-radio-producer, and the audience member asking the question was a middle-aged man with brown hair and glasses and a plodding, pedantic tone of voice.
The audience member went on, “I mean, there was a forest that the scientists wanted to save, and there was no money for it, so they got some hikers in there, and then they were able to raise money for it. So how can we get scientists to do more things like that? How can we convey to them that they need make their work relevant to people?”
I don’t know if he realized it, but his question was comparable to “Climate change is a scam concocted by environmentalists” in terms of being offensive to scientists. Continue reading “Basic Research: How asking weird questions about science builds the economy” »