Cardiac Reprogramming: From Developmental Biology to Regeneration
In Plain English:
How to turn the heart-dwelling cells that build connective tissues into replacements for damaged heart muscle cells
What it covered:
Dr. Deepak Srivastava is a cardiologist who experiments with using stem cells to create replacement cells for damaged heart muscle tissue. However, while most labs try to grow replacements in petri dishes, Dr. Srivastava’s lab is working on finding a way to transform the cells that build scar tissue in the heart (the cardiac fibroblasts) into fully functional heart muscle cells.
A typical fibroblast’s job is to secrete collagen and other chemicals that help the cells in muscle and skeletal tissues stick together. If they weren’t there, your muscle cells might slide around or come apart whenever you moved. Luckily, muscle cells like to form stringy structures called sarcomeres that can contract and release. When you’re flexing your muscles, you’re actually contracting the sarcomeres and that contractile force is what causes your arm to tense up. Without the fibroblasts, the muscle cells would have a hard time aligning themselves correctly (and if one cell is even slightly out of line with its neighbor cells, the rogue cell can throw everything off), so they’re a pretty important cell group. Continue reading “Stem Cell Science Double Feature: Reprogramming Cardiac Fibroblasts – Recap of talk by Dr. Deepak Srivastava” »